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Topic for genetic paper will be chosen at random based on a list which will be available during the first week of class. Each disorder has a genetic cause, and the gene(s) causing the problem are known. Paper on the genetic topic will be 850 words minimum, written into discrete sections. Word count does not include title, quoted material, or citations. At least 6 works cited will be used, 3 must be scientific journal papers or journal reviews (these are primary, peer-reviewed articles from journals like Nature or Science). Primary articles can be found through the link provided on Blackboard to PubMed. The Genetics Home Reference, Wiki, and the OMIM can be used, but are not considered primary sources. Web sites can be used, but not answers.com or webmd.com. See below as to how to set up each section (including giving the actual word counts) and exactly how to cite. Topic will be a genetic disorder, so information about the gene(s), gene name(s), inheritance pattern (or sporadic), and allele function (dominant, recessive, etc.) must be included, along with what is known about the function of the protein from that gene. If there are multiple genes involved, you may either use them all, or choose one and focus on that. That section is 250 words, minimum. Paper also must include what main organ system is affected and how it is affected, and what the organ system normally looks like and functions. Every symptom does not have to be listed, just the main symptoms. Must also discuss any treatment options, if available (if not, then state that there are no treatment options). That section is 450 words, minimum. At the end of the paper you will discuss why you personally think more funding toward research should be done on your disorder and the converse – why there should be less funding for research. Explain and defend your reasoning. This is for research about understanding the disorder and potentially finding new treatments; this is not increased funding for support groups, getting individuals to therapy, or increasing awareness of the disorder. That section is 150 words, minimum. 7 Word count does not apply to quotes, filler or rambling of the text which includes: repeating the assignment directions, why you found the topic interesting, where you can donate money / join a cause, discussions of any other non-genetic cause of the disorder, information about other genetic disorders, etc. Do not include tables, pictures, bullet points, or lists in your text. If direct quotes are to be used in the paper, they must be indicated with quotation marks and all quotes together cannot be more than 85 words. If quoting, you must include after the quote a summary of the quoted material in your own words. If more than 10% of the paper is in quotes the following deductions will be taken: Quotes are 11-25% of the paper: 50% grade reduction Quotes are 25-100% of the paper: 0 (zero) points for the paper It is the student’s responsibility to ensure that the paper is submitted in the correct format (.doc or .docx) via Blackboard. Paper is due by the beginning of class on the due date, and Blackboard will not accept any paper late. Do not wait too long to upload the paper; the system gets very busy toward the end of the semester. ‘System busy’ is not a legitimate excuse to justify a late submission. Discuss with the instructor if there is a problem or error with Blackboard that prohibits the submission of the paper, as errors can occur. Plagiarism of any kind will not be tolerated, and will result in a grade reduction on the assignment. All papers submitted through Blackboard are checked; if the plagiarism score is too high, you will receive a grade reduction. Citations and quoted material are not considered plagiarized, and those sections will be ignored by the program. Plagiarism score of 5-25%: 50% grade reduction Plagiarism score of 25-100%: 0 (zero) points for the paper Grade for the paper will be determined as follows (grading is very objective, either the material is there and you get all the points, or it is not so all points are deducted): Genetic pattern of inheritance: 10 pts Gene name: 10 pts Protein function: 5 pts Word count: 5 pts Treatment options: 5 pts Grammar: 4 pts In-text citations using number system: 5 pts Correct citation formatting: 10 pts Minimum number of required citations: 5 pts Normal organ function and aberrant organ function: 20 pts Discussion for increased research funding: 8 pts Discussion for decreased research funding: 8 pts Correct paper layout and formatting: 5 pts 8 Formatting and citations: Use this format to generally lay out your paper, where to put your actual word count numbers, and exactly how to cite. Genetics – Word Count: 250 Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Aenean commodo ligula eget dolor. Aenean massa. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Donec quam felis, ultricies nec, pellentesque eu, pretium quis, sem. Nulla consequat massa quis enim. Donec pede justo, fringilla vel, aliquet nec, vulputate eget, arcu. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. Nullam dictum felis eu pede mollis pretium. Integer tincidunt. . . Organ System Affected and Treatment Options – Word Count: 450 Cras dapibus. Vivamus elementum semper nisi. Aenean vulputate eleifend tellus. Aenean leo ligula, porttitor eu, consequat vitae, eleifend ac, enim. Aliquam lorem ante, dapibus in, viverra quis, feugiat a, tellus. Phasellus viverra nulla ut metus varius laoreet. Quisque rutrum. Aenean imperdiet. Etiam ultricies nisi vel augue. Curabitur ullamcorper ultricies nisi. Nam eget dui. Etiam rhoncus. Maecenas tempus, tellus eget condimentum rhoncus, sem quam semper libero, sit amet adipiscing sem neque sed ipsum. Nam quam nunc, blandit vel, luctus pulvinar, hendrerit id, lorem. Maecenas nec odio et ante tincidunt tempus. Donec vitae sapien ut libero venenatis faucibus. Nullam quis ante. Etiam sit amet orci eget eros faucibus tincidunt. Duis leo. Sed fringilla mauris sit amet nibh. . . Funding – Word Count: 150 Donec sodales sagittis magna. Sed consequat, leo eget bibendum sodales, augue velit cursus nunc, . . Whether you are summarizing or direct quoting, indicate your reference by parentheses and a number, or by using a superscript. The number refers to the actual citation, which will be ordered in the bibliography section alphabetically. Example: “This isn’t some paper that you can write the night before.” (5) “Great. I think I got it. But just in case, tell me the whole thing again, I wasn’t listening.”7 Journals will be cited with the author names, title of article, journal name, year, volume, and page numbers (in that order). Do not list the Html address of journals, doi numbers, or date of retrieval; you will receive no credit at all, even if the citation does include the needed material. Please note that even if a journal article is accessed online, do not cite it as a website; there is a journal and volume and page number, so cite it as a journal article. For website citations, remove any hyperlinks and do not list date of retrieval. Number the citations alphabetically using the first word listed. 1) Sacco-Casamassima, Goldstein, Birdsong, McIltrot, Abdullah, and Colombani. Z-type pattern pectus excavatum/carinatum in a case of Nonnan syndrome. Ann Thorac Surg. 2015. 99(5):1835-7. 2) Williams Syndrome. Wikipedia. http://en.wikipedia.org/wiki/Williams_syndrome

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